Oral Absorption Study Of Vitamin C Supplements
( A Preliminary Report )
To determine the plasma total ascorbate levels after oral gavage of
Ascorbic acid, Ester C and Crystal C at a dose of 8 mgs/kg body weight as equivalent
The mean Total Ascobate plasma concentrations ( micrograms/ml ) are given below:
The data are graphically presented in the shown chart.
3. Discussion of results:
The data shows, at equal ascorbate activity, administered as Ascorbic acid, Ester
C or Crystal C, Crystal C attained the highest plasma level at 30 minutes post dose.
Compared to Ester C, Crystal C attained a 41% higher plasma level at 30 minutes. Crystal
C plasma levels were 414% higher than Ascorbic acid at 30 minutes while Ester C was
only 260% higher. At 60 minutes Crystal C was 71%, and at 90 minutes, 160 % higher
than the corresponding plasma levels attained with Ester C. At 60 and 90 minutes the
plasma ascorbate concentrations from Ester C fell below both Crystal C and Ascorbic
The fourth point on each respective curve represents the result of regression analysis.
Ester C plasma levels return to baseline ( control ) levels approximately 105 minutes
post dose. Extrapolation predicts that Ascorbic acid plasma levels return to baseline
at 120 minutes and Crystal C approximately 180 minutes post dose.
The AUC ( area under the curve ) for Crystal C is in the range of 175% greater than
Ester C and 200% greater than Ascorbic acid plasma levels.
The AUC is a measure of Total Ascorbate activity delivered and thereby absorbed over
the test period.
At equal ascobate activity doses Crystal C attains higher ascorbate plasma levels
than Ester C or Ascorbic acid. These higher levels are maintained for the entire test
period. Crystal C delivers 175% more ascorbate activity than maintained by an equal
ascorbate activity dose of Ester C. The maintenance of plasma levels by Crystal C
is due to a more rapid and sustained oral uptake than Ester C or Ascorbic acid. This
is based on the fact that the down slopes of of the plasma levels are at the same
rate until return to baseline.
Study Prepared by:
Anthony J. Verlangieri, Ph. D
Professor of Pharmacology and Toxicology
University of Missisippi, School of Pharmacy.
January 10, 2004
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